A Mathematical Programming Formulation for the Budding Yeast Cell Cycle
نویسندگان
چکیده
منابع مشابه
A Mathematical Programming Formulation for the Budding Yeast Cell Cycle
The budding yeast cell cycle can be modeled by a set of ordinary differential equations with 143 rate constant parameters. The quality of the model (and an associated vector of parameter settings) is measured by comparing simulation results to the experimental data derived from observing the cell cycles of over 100 selected mutated forms. Unfortunately, determining whether the simulated phenoty...
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A novel topology of regulatory networks abstracted from the budding yeast cell cycle is studied by constructing a simple nonlinear model. A ternary positive feedback loop with only positive regulations is constructed with elements that activates the subsequent element in a clockwise fashion. A ternary negative feedback loop with only negative regulations is constructed with the elements that in...
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This report presents the definition, solution and validation of a stochastic model of the budding yeast cell cycle, based on Stochastic Petri Nets. A well-established deterministic model, based on ODEs, is considered as the basis for the stochastic modeling. A specific class of Stochastic Petri Nets is selected for building a stochastic version of the deterministic model, with applying the same...
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ژورنال
عنوان ژورنال: SIMULATION
سال: 2007
ISSN: 0037-5497,1741-3133
DOI: 10.1177/0037549707085075